First insights into northern Africa high-altitude background aerosol chemical composition and source influences

Lungs at high-altitude: genomic insights into hypoxic responses.

Hypobaric hypoxia at high altitude (HA) results in reduced blood arterial oxygen saturation, perfusion of organs with hypoxemic blood, and direct hypoxia of lung tissues. The pulmonary complications in the cells of the pulmonary arterioles due to hypobaric hypoxia are the basis of the pathophysiological mechanisms of high-altitude pulmonary edema (HAPE). Some populations that have dwelled at HA...

Functional Genomic Insights into Regulatory Mechanisms of High-Altitude Adaptation.

Recent studies of indigenous human populations at high altitude have provided proof-of-principle that genome scans of DNA polymorphism can be used to identify candidate loci for hypoxia adaptation. When integrated with experimental analyses of physiological phenotypes, genome-wide surveys of DNA polymorphism and tissue-specific transcriptional profiles can provide insights into actual mechanism...

Chemical composition of the Jungfraujoch aerosol

J. Cozic, B. Verheggen, E. Weingartner, J. Crosier, K. Bower, M. Flynn, H. Coe, S. Henning, M. Steinbacher, M. Collaud Coen, A. Petzold, and U. Baltensperger Laboratory for Atmospheric Chemistry, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland School of Earth, Atmospheric and Environmental Sciences, University of Manchester, M60 1QD, UK Leibniz-Institute for Tropospheric Research, 043...

Unravelling the Pathogenesis of Severe COVID-19 Pneumonia: Are There Possible Insights From High Altitude?

Observational insights into aerosol formation from isoprene.

Atmospheric photooxidation of isoprene is an important source of secondary organic aerosol (SOA) and there is increasing evidence that anthropogenic oxidant emissions can enhance this SOA formation. In this work, we use ambient observations of organosulfates formed from isoprene epoxydiols (IEPOX) and methacrylic acid epoxide (MAE) and a broad suite of chemical measurements to investigate the r...